Changelian, P. S.: search on Z-Library

The world's largest scientific articles store. 70,000,000+ articles for free.

Don't use scam websites

1

Translational and clinical advances in JAK-STAT biology: The present and future of jakinibs

Gadina, Massimo, Johnson, Catrina, Schwartz, Daniella, Bonelli, Michael, Hasni, Sarfaraz, Kanno, Yuka, Changelian, Paul, Laurence, Arian, O'Shea, John J.

Journal:

Journal of Leukocyte Biology

Year:

2018

Language:

english

File:

PDF, 370 KB

english, 2018

2

Hierarchy of Protein Tyrosine Kinases in Interleukin-2 (IL-2) Signaling: Activation of Syk Depends on Jak3; However, Neither Syk nor Lck Is Required for IL-2-Mediated STAT Activation

Zhou, Y.-J., Magnuson, K. S., Cheng, T. P., Gadina, M., Frucht, D. M., Galon, J., Candotti, F., Geahlen, R. L., Changelian, P. S., O'Shea, J. J.

Journal:

Molecular and Cellular Biology

Year:

2000

Language:

english

File:

PDF, 1.05 MB

english, 2000

3

Role of tyrosine kinases in lymphocyte activation: Targets for drug intervention

J. H. Hanke, B. A. Pollok, P. S. Changelian

Journal:

Inflammation Research

Year:

1995

Language:

english

File:

PDF, 2.05 MB

english, 1995

4

Janus kinase 3 inhibition with CP-690,550 prevents allograft vasculopathy

Geraldine Rousvoal, Ming-Sing Si, Macy Lau, Sally Zhang, Gerald J. Berry, Mona G. Flores, Paul S. Changelian, Bruce A. Reitz, Dominic C. Borie

Journal:

Transplant International

Year:

2006

Language:

english

File:

PDF, 330 KB

english, 2006

5

Double-Blind, Placebo-Controlled, Dose-Escalation Study to Evaluate the Pharmacologic Effect of CP-690,550 in Patients With Psoriasis

Boy, Mary G, Wang, Cunshan, Wilkinson, Bethanie E, Chow, Vincent Fung-Sing, Clucas, Alan T, Krueger, James G, Gaweco, Anderson S, Zwillich, Samuel H, Changelian, Paul S, Chan, Gary

Journal:

The Journal of Investigative Dermatology

Year:

2009

Language:

english

File:

PDF, 15.74 MB

english, 2009

6

A new modality for immunosuppression: targeting the JAK/STAT pathway

O'Shea, John J., Pesu, Marko, Borie, Dominic C., Changelian, Paul S.

Journal:

Nature Reviews Drug Discovery

Year:

2004

Language:

english

File:

PDF, 272 KB

english, 2004

7

The specificity of JAK3 kinase inhibitors

Changelian, P. S., Moshinsky, D., Kuhn, C. F., Flanagan, M. E., Munchhof, M. J., Harris, T. M., Whipple, D. A., Doty, J. L., Sun, J., Kent, C. R.

Journal:

Year:

2008

Language:

english

File:

PDF, 248 KB

english, 2008

8

The Novel JAK-3 Inhibitor CP-690550 Is a Potent Immunosuppressive Agent in Various Murine Models

Elizabeth Kudlacz, Bret Perry, Perry Sawyer, Maryrose Conklyn, Sandra McCurdy, William Brissette, Mark Flanagan, and Paul Changelian

Journal:

American Journal of Transplantation

Year:

2004

Language:

english

File:

PDF, 116 KB

english, 2004

9

Purification of the growth-associated protein GAP-43 by reversed phase chromatography: amino acid sequence analysis and cDNA identification

Paul S. Changelian, Karina Meiri, Daniel Soppet, Helen Valenza, Arleen Loewy, Mark Willard

Journal:

Year:

1990

Language:

english

File:

PDF, 1.15 MB

english, 1990

10

In vivo augmentation of IFN-γ with a rIL-12 human/mouse chimera: Pleiotropic effects against infectious agents in mice and rats

Ronald P. Gladue, Ann M. Laquerre, Holly A. Magna, Laurie A. Carroll, Michele O'Donnell, Paul S. Changelian, Arthur E. Franke

Journal:

Year:

1994

Language:

english

File:

PDF, 1.29 MB

english, 1994

11

Jak3 and the pathogenesis of severe combined immunodeficiency

John J O’Shea, Matthew Husa, Denise Li, Sigrun R Hofmann, Wendy Watford, Joseph L Roberts, Rebecca H Buckley, Paul Changelian, Fabio Candotti

Journal:

Molecular Immunology

Year:

2004

Language:

english

File:

PDF, 240 KB

english, 2004

12

JAK3 inhibition, a viable new modality of immunosuppression for solid organ transplants

Dominic C. Borie, John J. O'Shea, Paul S. Changelian

Journal:

Trends in Molecular Medicine

Year:

2004

Language:

english

File:

PDF, 602 KB

english, 2004

13

The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia

Elizabeth Kudlacz, Maryrose Conklyn, Catharine Andresen, Carrie Whitney-Pickett, Paul Changelian

Journal:

European Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 463 KB

english, 2008

14

Immunoprecipitation with two-dimensional pools as a hybridoma screening technique: Production and characterization of monoclonal antibodies against adenovirus 2 proteins

Constance L. Cepko, Paul S. Changelian, Phillip A. Sharp

Journal:

Year:

1981

Language:

english

File:

PDF, 1.37 MB

english, 1981

15

Jakinibs: a new class of kinase inhibitors in cancer and autoimmune disease

Kontzias, Apostolos, Kotlyar, Alexander, Laurence, Arian, Changelian, Paul, O'Shea, John J

Journal:

Current Opinion in Pharmacology

Year:

2012

Language:

english

File:

PDF, 486 KB

english, 2012

16

The Amino Terminus of JAK3 is Necessary and Sufficient for Binding to the Common γ Chain and Confers the Ability to Transmit Interleukin 2-mediated Signals

Min Chen, Alan Cheng, Yi-Qing Chen, Anka Hymel, Eric P. Hanson, Lida Kimmel, Yasuhiro Minami, Tadatsugu Taniguchi, Paul S. Changelian and John J. O'Shea

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.36 MB

english, 1997

17

Distinct Tyrosine Phosphorylation Sites in JAK3 Kinase Domain Positively and Negatively Regulate Its Enzymatic Activity

Yong-Jie Zhou, Eric P. Hanson, Yi-Qing Chen, Kelly Magnuson, Min Chen, Patrick G. Swann, Ronald L. Wange, Paul S. Changelian and John J. O'Shea

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.82 MB

english, 1997

18

Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

Changelian, P. S.

Journal:

Year:

2003

Language:

english

File:

PDF, 332 KB

english, 2003

19

Ecto-5'-Nucleotidase (CD73) Attenuates Allograft Airway Rejection through Adenosine 2A Receptor Stimulation

Ohtsuka, T., Changelian, P. S., Bouis, D., Noon, K., Harada, H., Lama, V. N., Pinsky, D. J.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 826 KB

english, 2010

20

Tissue-specific phosphorylation of complement receptors CR1 and CR2

Changelian, P. S.

Journal:

Journal of Experimental Medicine

Year:

1986

Language:

english

File:

PDF, 1.65 MB

english, 1986

21

Proline Residues in Cd28 and the Src Homology (Sh)3 Domain of Lck Are Required for T Cell Costimulation

Holdorf, A. D., Green, J. M., Levin, S. D., Denny, M. F., Straus, D. B., Link, V., Changelian, P. S., Allen, P. M., Shaw, A. S.

Journal:

Journal of Experimental Medicine

Year:

1999

Language:

english

File:

PDF, 133 KB

english, 1999

22

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor: STUDY OF Lck- AND FynT-DEPENDENT T CELL ACTIVATION

Hanke, J. H., Gardner, J. P., Dow, R. L., Changelian, P. S., Brissette, W. H., Weringer, E. J., Pollok, B. A., Connelly, P. A.

Journal:

Journal of Biological Chemistry

Year:

1996

Language:

english

File:

PDF, 682 KB

english, 1996

23

MALDI mass spectrometry imaging analysis of pituitary adenomas for near-real-time tumor delineation

Calligaris, David, Feldman, Daniel R., Norton, Isaiah, Olubiyi, Olutayo, Changelian, Armen N., Machaidze, Revaz, Vestal, Matthew L., Laws, Edward R., Dunn, Ian F., Santagata, Sandro, Agar, Nathalie Y.

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1.17 MB

english, 2015

24

Genetic Ablation of the src Kinase p59fynT Exacerbates Pulmonary Inflammation in an Allergic Mouse Model

Kudlacz, Elizabeth M., Andresen, Catharine J., Salafia, Michelle, Whitney, Carrie A., Naclerio, Barbara, Changelian, Paul S.

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2001

Language:

english

File:

PDF, 187 KB

english, 2001

25

Profiling of adrenocorticotropic hormone and arginine vasopressin in human pituitary gland and tumor thin tissue sections using droplet-based liquid-microjunction surface-sampling-HPLC–ESI-MS–MS

Kertesz, Vilmos, Calligaris, David, Feldman, Daniel R., Changelian, Armen, Laws, Edward R., Santagata, Sandro, Agar, Nathalie Y. R., Van Berkel, Gary J.

Journal:

Analytical and Bioanalytical Chemistry

Year:

2015

Language:

english

File:

PDF, 4.70 MB

english, 2015

26

SUPERARRAY ANALYSIS OF TRACHEAL TRANSPLANTS UNDER JAK3-TARGETED IMMUNOSUPPRESSION REVEALS A ROLE FOR THE B-CELL CHEMOATTRACTANTS BLC-BCA 1 AND SDF1α.

Lau, M, Zhang, S, Berry, G, Si, M -S., Rousvoal, G, Larson, M, Hawkins, J, Flores, M, Changelian, P, Reitz, B, Borie, D

Journal:

Transplantation Journal

Year:

2004

Language:

english

File:

PDF, 896 KB

english, 2004

27

JAK3 INHIBITION WITH CP-690,550 PREVENTS OBLITERATIVE BRONCHIOLITIS IN A RAT TRACHEAL TRANSPLANT MODEL.

Rousvoal, G, Zhang, S, Berry, G, Lau, M, Larson, M, Si, M-S, Flores, M, Hawkins, J, Changelian, P, Reitz, B, Borie, D

Journal:

Transplantation Journal

Year:

2004

Language:

english

File:

PDF, 484 KB

english, 2004

28

PREVENTION OF OBLITERATIVE BRONCHIOLITIS BY JAK 3 INHIBITION WITH CP-690,550 IS ACCOMPANIED BY A DISTINCT GROWTH FACTOR GENE EXPRESSION PROFILE.

Zhang, S, Lau, M, Berry, G, Larson, M, Rousvoal, G, Si, M -S., Hawkins, J, Flores, M, Changelian, P, Morris, R, Reitz, B, Borie, D

Journal:

Transplantation Journal

Year:

2004

Language:

english

File:

PDF, 896 KB

english, 2004

29

First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development

Jonas, Oliver, Calligaris, David, Methuku, Kashi Reddy, Poe, Michael M., Francois, Jessica Pierre, Tranghese, Frank, Changelian, Armen, Sieghart, Werner, Ernst, Margot, Pomeranz Krummel, Daniel A., Co

Journal:

Journal of Biomedical Nanotechnology

Year:

2016

Language:

english

File:

PDF, 8.17 MB

english, 2016

30

Janus kinase 3 inhibition for immunosuppression: getting closer to the starting line

Borie, Dominic C, Starr, Robyn, Hendry, Stephen, Changelian, Paul S, Shea, John O??

Journal:

Current Opinion in Organ Transplantation

Year:

2005

Language:

english

File:

PDF, 233 KB

english, 2005

31

Quantitative Analysis of the Immunosuppressant CP-690,550 in Whole Blood by Column-Switching High-Performance Liquid Chromatography and Mass Spectrometry Detection

Paniagua, Ricardo, Campbell, Andrew, Changelian, Paul S, Reitz, Bruce A, Prakash, Chandra, Borie, Dominic C

Journal:

Therapeutic Drug Monitoring

Year:

2005

Language:

english

File:

PDF, 408 KB

english, 2005

32

Immunosuppression by the JAK3 Inhibitor CP-690,550 Delays Rejection and Significantly Prolongs Kidney Allograft Survival in Nonhuman Primates

Borie, Dominic C., Changelian, Paul S., Larson, Michael J., Si, Ming-Sing, Paniagua, Ricardo, Higgins, John P., Holm, Bari, Campbell, Andrew, Lau, Macy, Zhang, Sally, Flores, Mona G., Rousvoal, Gerald

Journal:

Transplantation Journal

Year:

2005

Language:

english

File:

PDF, 1.11 MB

english, 2005

33

Structure of the NGFI-A gene and detection of upstream sequences responsible for its transcriptional induction by nerve growth factor.

Changelian, P. S., Feng, P., King, T. C., Milbrandt, J.

Journal:

Proceedings of the National Academy of Sciences

Year:

1989

Language:

english

File:

PDF, 1.22 MB

english, 1989

34

New strategies for immunosuppression: interfering with cytokines by targeting the Jak/Stat pathway

O??Shea, John J, Park, Heiyoung, Pesu, Marko, Borie, Dominic, Changelian, Paul

Journal:

Current Opinion in Rheumatology

Year:

2005

Language:

english

File:

PDF, 348 KB

english, 2005

35

Effects of JAK3 Inhibition with CP-690,550 on Immune Cell Populations and Their Functions in Nonhuman Primate Recipients of Kidney Allografts

Paniagua, Ricardo, Si, Ming-Sing, Flores, Mona G., Rousvoal, Geraldine, Zhang, Sally, Aalami, Oliver, Campbell, Andrew, Changelian, Paul S., Reitz, Bruce A., Borie1, Dominic C.

Journal:

Transplantation Journal

Year:

2005

Language:

english

File:

PDF, 1.24 MB

english, 2005

36

Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity

Zhou, Y.-J., Hanson, E. P., Chen, Y.-Q., Magnuson, K., Chen, M., Swann, P. G., Wange, R. L., Changelian, P. S., O'Shea, J. J.

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 280 KB

english, 1997

37

HSP90 Inhibition Enhances Antimitotic Drug-Induced Mitotic Arrest and Cell Death in Preclinical Models of Non-Small Cell Lung Cancer

O'Connell, Brenda C., O'Callaghan, Katie, Tillotson, Bonnie, Douglas, Mark, Hafeez, Nafeeza, West, Kip A., Stern, Howard, Ali, Janid A., Changelian, Paul, Fritz, Christian C., Palombella, Vito J., McG

Journal:

Year:

2014

Language:

english

File:

PDF, 2.14 MB

english, 2014

38

1064 JAK kinase inhibitors efficiaous in models of murine contact hypersensitivity

Changelian, P., Mnich, S., Xu, C., Hockerman, S., Anderson, D., Jacobsen, J., Monahan, J.

Journal:

The Journal of Investigative Dermatology

Year:

2018

Language:

english

File:

PDF, 238 KB

english, 2018

39

The amino terminus of JAK3 is necessary and sufficient for binding to the common chain and confers the ability to transmit interleukin 2-mediated signals

Chen, M., Cheng, A., Chen, Y.-Q., Hymel, A., Hanson, E. P., Kimmel, L., Minami, Y., Taniguchi, T., Changelian, P. S., O'Shea, J. J.

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 415 KB

english, 1997

40

Substrate-based kinase activity inference identifies MK2 as driver of colitis

Strasser, Samantha Dale, Ghazi, Phaedra C, Starchenko, Alina, Boukhali, Myriam, Edwards, Amanda, Suarez-Lopez, Lucia, Lyons, Jesse, Changelian, Paul S, Monahan, Joseph B, Jacobsen, Jon, Brubaker, Doug

Journal:

Integrative Biology

Year:

2019

Language:

english

File:

PDF, 1.48 MB

english, 2019

41

Substrate-based kinase activity inference identifies MK2 as driver of colitis

Strasser, Samantha Dale, Ghazi, Phaedra C, Starchenko, Alina, Boukhali, Myriam, Edwards, Amanda, Suarez-Lopez, Lucia, Lyons, Jesse, Changelian, Paul S, Monahan, Joseph B, Jacobsen, Jon, Brubaker, Doug

Journal:

Integrative Biology

Year:

2019

File:

PDF, 1.48 MB

2019

42

Translating JAKs to Jakinibs

Gadina, Massimo, Chisolm, Danielle A., Philips, Rachael L., McInness, Iain B., Changelian, Paul S., OâShea, John J.

Journal:

The Journal of Immunology

Year:

2020

File:

PDF, 1.14 MB

2020